Redox signaling by reactive electrophiles and oxidants
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the …
Reactive oxygen species and reactive nitrogen species are biological molecules that play
important roles in cardiovascular physiology and contribute to disease initiation …
important roles in cardiovascular physiology and contribute to disease initiation …
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis
Vascular endothelial growth factor receptor type 2 (VEGFR2, also known as KDR and FLK1)
signalling in endothelial cells (ECs) is essential for developmental and reparative …
signalling in endothelial cells (ECs) is essential for developmental and reparative …
[HTML][HTML] Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-sulfhydration
J Zivanovic, E Kouroussis, JB Kohl, B Adhikari… - Cell metabolism, 2019 - cell.com
Life on Earth emerged in a hydrogen sulfide (H 2 S)-rich environment eons ago and with it
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …
Effects of ionizing radiation on biological molecules—mechanisms of damage and emerging methods of detection
Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …
series of events that are amplified by endogenous signaling and culminating in oxidative …
[HTML][HTML] Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery
CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …
respectively, are produced during normal cell function and in response to various stimuli. An …
[HTML][HTML] Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism
DC Liemburg-Apers, PHGM Willems… - Archives of …, 2015 - Springer
Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly
balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce …
balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce …
[HTML][HTML] Sulfenic acid chemistry, detection and cellular lifetime
V Gupta, KS Carroll - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
Background Reactive oxygen species-mediated cysteine sulfenic acid modification has
emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic …
emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic …
[HTML][HTML] Chemical methods for mapping cysteine oxidation
Cysteine residues in proteins are subject to diverse redox chemistry. Oxidation of cysteine to
S-nitrosocysteine, cysteine sulfenic and sulfinic acids, disulfides and persulfides are a few …
S-nitrosocysteine, cysteine sulfenic and sulfinic acids, disulfides and persulfides are a few …
Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity
Protein sulfenylation is a post-translational modification of emerging importance in higher
eukaryotes. However, investigation of its diverse roles remains challenging, particularly …
eukaryotes. However, investigation of its diverse roles remains challenging, particularly …