Bioactive substances, displaying excellent biocompatibility, chemical stability, and
processability, could be extensively applied in biomedicine and tissue engineering. In recent …

A review of the pharmacological applications of lignins provides evidence of their protective
role against the development of different diseases. In many cases, the effects of lignins could …

The objectives of the present study were to investigate whether kaempferol affects pro-
coagulant proteinase activity, fibrin clot formation, blood clot and thrombin (or …

Highlights•Isolation of rutin from Dendropanax morbifera Leveille with anti-thrombotic
activity.•Rutin was found to inhibit fibrin clotting and thrombin activity effectively.•Rutin …

Growing evidence suggests that plasmin is involved in a number of physiological processes
in addition to its key role in fibrin cleavage. Plasmin inhibition is critical in preventing …

A novel food-derived anticoagulant heptapeptides (P-3-CG) was isolated and characterized
from oyster (Crassostrea gigas) pepsin hydrolysate. P-3-CG competed with fibrinogen …

The present study evaluates the in vitro, in vivo, and ex vivo antithrombotic and
anticoagulant effect of two flavonoids: quercetin and quercetin‐3‐O‐β‐d‐glucoside …

Essentials• Allosteric inhibition is a promising method for reducing bleeding risk associated
with anticoagulants.• Sulfated β‐O4 lignin (SbO4L) targets exosite 2 of thrombin to induce …

Sulfated low molecular weight lignins (LMWLs) have been found to bind in the heparin
binding sites of coagulation proteinases. LMWLs represent a library of diverse non …

The catalytic activity of enzymes can be regulated by interactions with synthetic
nanoparticles (NPs) in a number of ways. To date, however, the potential use of NPs as …