Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …

Gene therapy provides a promising strategy for curing monogenetic disorders and complex
diseases. However, there are challenges associated with the use of viral delivery vectors …

Liver transplantation has become an immense success; nevertheless, far more recipients
are registered on waiting lists than there are available donor livers for transplantation. High …

Importance Early allograft dysfunction (EAD) following a liver transplant (LT) unequivocally
portends adverse graft and patient outcomes, but a widely accepted classification or grading …

More than 25 years after its discovery, the post-transcriptional gene regulation mechanism
termed RNAi is now transforming pharmaceutical development, proved by the recent FDA …

The nucleotide-binding domain leucine-rich repeat-receptor, pyrin domain-containing-3
(NLRP3) inflammasome contributes to the inflammatory response by activating caspase-1 …

With the increasing number of accepted candidates on waiting lists worldwide, there is an
urgent need to expand the number and the quality of donor livers. Dynamic preservation …

Because of the high demand of organs, the usage of marginal grafts has increased. These
marginal organs have a higher risk of developing ischemia-reperfusion injury, which can …

The number of waitlisted lung transplant candidates exceeds the availability of donor
organs. Barriers to utilization of donor lungs include suboptimal lung allograft function, long …

Background & Aims Early allograft dysfunction (EAD) following liver transplantation (LT)
negatively impacts graft and patient outcomes. Previously we reported that the liver graft …