The emergence of drug resistance is the most substantial challenge to the effectiveness of
anticancer therapies. Orthogonal approaches have revealed that a subset of cells, known as …

Background Many biological processes, such as cell division cycle and drug resistance, are
reflected in protein covariation across single cells. This covariation can be quantified and …

The inherent stochasticity in the gene product levels can drive single cells within an
isoclonal population to different phenotypic states. The dynamic nature of this intercellular …

A common feature of bacterial, fungal and cancer cell populations upon treatment is the
presence of tolerant and persistent cells able to survive, and sometimes grow, even in the …

Assigning single cell transcriptomes to cellular lineage trees by lineage tracing has
transformed our understanding of differentiation during development, regeneration, and …

High-grade serous ovarian cancer (HGSOC) represents the most common and lethal
subtype of ovarian cancer. Despite initial response to platinum-based standard therapy …

Nongenetic plasticity has emerged as a key driver of cancer drug resistance, yet its precise
origins, nature, and consequences are not fully clarified. This review examines …

Cationic oncolytic polypeptides have gained increasing attention owing to their ability to
directly lyse cancer cells and activate potent antitumor immunity. However, the low tumor cell …

Cancer cells exhibit dramatic differences in gene expression at the single-cell level, which
can predict whether they become resistant to treatment. Treatment perpetuates this …

Cellular responses to environmental stimuli are typically thought to be governed by
genetically encoded programs. We demonstrate that melanoma cells can form and maintain …