One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Chronic constipation is a prevalent condition that severely impacts the quality of life of those
affected. Several types of primary chronic constipation, which show substantial overlap …

The enteric nervous system (ENS) is an extensive network comprising millions of neurons
and glial cells contained within the wall of the gastrointestinal tract. The major functions of …

Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the
gastrointestinal tract, but the signaling processes that link immune activation with visceral …

The gastrointestinal tract contains its own set of intrinsic neuroglial circuits—the enteric
nervous system (ENS)—which detects and responds to diverse signals from the …

At the most fundamental level, the bowel facilitates absorption of small molecules, regulates
fluid and electrolyte flux, and eliminates waste. To successfully coordinate this complex …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Background & Aims When the glial fibrillary acidic protein (GFAP) promoter is used to
express cellular toxins that eliminate glia in mice, intestinal epithelial permeability and …

Glia (from Greek γλοία meaning 'glue') pertains to non‐neuronal cells in the central (CNS)
and peripheral nervous system (PNS) that nourish neurons and maintain homeostasis. In …