Mitochondria have long been known to be the powerhouses of the cell but they also
contribute to redox and Ca 2+ homeostasis, provide intermediary metabolites and store …

Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

The aim of this study was to investigate the effect of Krebs cycle intermediates on basal and
quinolinic acid (QA)-or iron-induced TBARS production in brain membranes. Oxaloacetate …

Mitochondria play a central and multifaceted role in the mammalian egg and early embryo,
contributing to many different aspects of early development. While the contribution of …

Energy homeostasis of the oocyte is a crucial determinant of fertility. Following ovulation, the
oocyte is exposed to the unique environment of the Fallopian tube, and this is reflected in a …

Bacteria have survived, and many have thrived, since antiquity in the presence of the highly‐
reactive chalcogen—oxygen (O2). They are known to evoke intricate strategies to defend …

Oxidative stress is implicated in neurodegenerative diseases including stroke, Alzheimer's
disease and Parkinson's disease, and has been extensively studied as a potential target for …

The prognosis for cardiac arrest victims remains dismal, as only 17% survives to hospital
discharge. Post-resuscitation myocardial stunning is the mechanical dysfunction that …

Background and Purpose—Pyruvate is known to be cytoprotective through antioxidant and
anti-inflammatory mechanisms. We tested the hypothesis that pyruvate protects the brain …

Because it is the product of glycolysis and main substrate for mitochondrial respiration,
lactate is the central metabolic intermediate in cerebral energy substrate delivery. Our recent …