[HTML][HTML] AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation

M Entezari, D Hashemi, A Taheriazam… - Biomedicine & …, 2022 - Elsevier
Diabetes mellitus (DM) is considered as a main challenge in both developing and
developed countries, as lifestyle has changed and its management seems to be vital. Type I …

Addressing the preventive and therapeutic perspective of berberine against diabetes

S Shrivastava, A Sharma, N Saxena, R Bhamra… - Heliyon, 2023 - cell.com
Diabetes has emerged as one the leading detrimental factors for human life expectancy
worldwide. The disease is mainly considered as outcome of dysregulation in glucose …

Withametelin, a steroidal lactone, isolated from datura innoxa attenuates STZ-induced diabetic neuropathic pain in rats through inhibition of NF-kB/MAPK signaling

A Khan, B Shal, AU Khan, MW Baig, I Ul Haq… - Food and Chemical …, 2023 - Elsevier
Diabetic neuropathic pain is one of the microvascular complications of diabetes mellitus
characterized by symmetrical pain and sensory abnormalities. A steroidal lactone isolated …

Target recognition and network pharmacology for revealing anti-diabetes mechanisms of natural product

Y Wang, B Hu, S Feng, J Wang, F Zhang - Journal of Computational …, 2020 - Elsevier
Diabetes is a metabolic disease characterized by persistent hyperglycemia, which results in
serious complications such as cardiovascular disorder, neuropathy, renal failure, and …

Pharmacological evaluation of Thuja occidentalis for the attenuation of neuropathy via AGEs and TNF-α inhibition in diabetic neuropathic rats

SK Bhargava, TG Singh, A Mannan, S Singh… - … Science and Pollution …, 2022 - Springer
When diabetes neuropathy occurs, the oxidative stress caused by chronic hyperglycemia
may result in chronic neuronal damage. To mitigate the effects of hyperglycemia-induced …

Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: Possible therapeutic intervention of rutin and quercetin

TF Roohi, S Mehdi, S Aarfi, KL Krishna, S Pathak… - Diabetology …, 2024 - Springer
Diabetic nephropathy and peripheral neuropathy are the two main complications of chronic
diabetes that contribute to high morbidity and mortality. These conditions are characterized …

NF-ĸB axis in diabetic neuropathy, cardiomyopathy and nephropathy: A roadmap from molecular intervention to therapeutic strategies

A Rezaee, P Rahmanian, A Nemati, F Sohrabifard… - Heliyon, 2024 - cell.com
Diabetes mellitus (DM) is a metabolic illness defined by elevated blood glucose levels,
mediating various tissue alterations, including the dysfunction of vital organs. Diabetes …

Effects of Tang Luo Ning on diabetic peripheral neuropathy in rats revealed by LC–MS metabolomics approach

Y Li, W Yao, Y Gao - Biomedical Chromatography, 2022 - Wiley Online Library
Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes
with limited therapies. Tang Luo Ning (TLN), a traditional Chinese medicine compound, has …

Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status

S Mohammad, T Mahmood, A Shamim, F Ahsan… - Drug …, 2024 - thieme-connect.com
Glipizide is an oral glucose-lowering medication that is beneficial for the treatment of type 2
diabetes. This study compiles exhaustively all accessible information on glipizide, from …

Diabetic Neuropathy: An Overview of Molecular Pathways and Protective Mechanisms of Phytobioactives

M Hashim, J Akhtar, MI Khan, M Ahmad… - … Metabolic & Immune …, 2024 - ingentaconnect.com
Diabetic neuropathy (DN) is a common and debilitating complication of diabetes mellitus
that affects the peripheral nerves and causes pain, numbness, and impaired function. The …