MicroRNAs as biomarkers for liver disease and hepatocellular carcinoma

CN Hayes, K Chayama - International journal of molecular sciences, 2016 - mdpi.com
Serum levels of liver enzymes, such as alanine transaminase, aspartate transaminase, and
α-fetoprotein, provide insight into liver function and are used during treatment of liver …

Fructose-mediated effects on gene expression and epigenetic mechanisms associated with NAFLD pathogenesis

JK DiStefano - Cellular and Molecular Life Sciences, 2020 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a chronic, frequently progressive condition that
develops in response to excessive hepatocyte fat accumulation (ie, steatosis) in the absence …

Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury

JC Mossanen, O Krenkel, C Ergen, O Govaere… - Hepatology, 2016 - journals.lww.com
Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure
(ALF) in humans and induces hepatocyte necrosis, followed by activation of the innate …

[PDF][PDF] Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

VM Lauschke, SU Vorrink, SML Moro, F Rezayee… - …, 2016 - Wiley Online Library
Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing
differentiated and dedifferentiated proliferating states in vivo. However, in two‐dimensional …

Four susceptibility loci for gallstone disease identified in a meta-analysis of genome-wide association studies

AD Joshi, C Andersson, S Buch, S Stender, R Noordam… - Gastroenterology, 2016 - Elsevier
Background & Aims A genome-wide association study (GWAS) of 280 cases identified the
hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease …

Fishing into the MicroRNA transcriptome

ME Herkenhoff, AC Oliveira, PG Nachtigall… - Frontiers in …, 2018 - frontiersin.org
In the last decade, several studies have been focused on revealing the microRNA (miRNA)
repertoire and determining their functions in farm animals such as poultry, pigs, cattle, and …

Missing heritability of common diseases and treatments outside the protein-coding exome

W Sadee, K Hartmann, M Seweryn, M Pietrzak… - Human genetics, 2014 - Springer
Genetic factors strongly influence risk of common human diseases and treatment outcomes
but the causative variants remain largely unknown; this gap has been called the 'missing …

A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection

KJ Siddle, M Deschamps, L Tailleux… - Genome …, 2014 - genome.cshlp.org
MicroRNAs (miRNAs) are critical regulators of gene expression, and their role in a wide
variety of biological processes, including host antimicrobial defense, is increasingly well …

Age-dependent hepatic UDP-glucuronosyltransferase gene expression and activity in children

E Neumann, H Mehboob, J Ramírez, S Mirkov… - Frontiers in …, 2016 - frontiersin.org
UDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes.
The aim of this study was to explore the relationship between age and changes in mRNA …

Exploring genetic associations with ceRNA regulation in the human genome

MJ Li, J Zhang, Q Liang, C Xuan, J Wu… - Nucleic acids …, 2017 - academic.oup.com
Competing endogenous RNAs (ceRNAs) are RNA molecules that sequester shared
microRNAs (miRNAs) thereby affecting the expression of other targets of the miRNAs …