Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and
have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four …

Statins are the most widely used pharmacological agents for reducing blood cholesterol
levels and treating atherosclerotic cardiovascular diseases. Most of the statins' derivatives …

Background Coronavirus disease 2019 (COVID-19) might affect everyone, but people with
comorbidities such as hypertension and cardiovascular disease (CVD) may often have more …

Inflammation plays a critical role in several diseases such as cancer, gastric, heart and
nervous system diseases. Data suggest that the activation of mammalian target of rapamycin …

In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on
apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these …

Background. Elevated serum low‐density lipoproteins (LDL), the substrate for the formation
of atherogenic oxidized LDLs (oxLDL), are a causal factor for atherosclerotic cardiovascular …

Efferocytosis (clearance of apoptotic cells by phagocytosis without inducing inflammation
and autoimmunity) is an important mechanism in the resolution of inflammatory processes …

Highlights•Nanomedicine has emerged as a field with great opportunities to improve
treatment strategies.•Pulmonary arterial hypertension (PAH) is a serious and incurable …

Abdominal aortic aneurysm (AAA) is a prevalent condition which causes progressive growth
and rupture of aortic wall with a high death rate. Several studies have found that treatment …

Adverse cardiovascular disease (CVD) outcomes, such as sudden cardiac death, acute
myocardial infarction, and stroke, are often catastrophic. Statins are frequently used to …