The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein
kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG …

Protein kinases are involved in the regulation of many cellular processes including cell
differentiation, survival, migration, axon guidance and neuronal plasticity. A growing set of …

The rhodium-catalyzed ortho-alkenylation of phenyl sulfoxides using alkenes or alkynes as
substituent sources proceeds efficiently through sulfoxide group directed C–H bond …

The protein kinase PDK1 phosphorylates at least 24 distinct substrates, all of which belong
to the AGC protein kinase group. Some substrates, such as conventional PKCs, undergo …

ABSTRACT Introduction: 3-Phosphoinositide-dependent kinase 1 (PDK1), the 'master
kinase of the AGC protein kinase family', plays a key role in cancer development and …

The protein kinase C-related kinases (PRKs, also termed PKNs) are important in cell
migration, cancer, hepatitis C infection, and nutrient sensing. They belong to a group of …

The rational design of allosteric kinase modulators is challenging but rewarding. The protein
kinase PDK1, which lies at the center of the growth‐factor signaling pathway, possesses an …

There is a current and pressing need for improved cancer therapies. The use of small
molecule kinase inhibitors and their application in combinatorial regimens represent an …

PDK1, an attractive cancer target that downstreams 23 other kinases towards cell growth,
survival and metabolism has gaining attention due to allosteric effect of ligands bound to it …

Sulfur-containing compounds are a class of important motifs extensively applied in
pharmaceutical and pesticidal industries as well as in electrochemistry, toxicant separation …