Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Self‐assembling peptide‐based hydrogels for wound tissue repair

T Guan, J Li, C Chen, Y Liu - Advanced Science, 2022 - Wiley Online Library
Wound healing is a long‐term, multistage biological process that includes hemostasis,
inflammation, proliferation, and tissue remodeling and requires intelligent designs to provide …

Tailoring materials for modulation of macrophage fate

J Li, X Jiang, H Li, M Gelinsky, Z Gu - Advanced Materials, 2021 - Wiley Online Library
Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

Multifunctional hydrogels for the healing of diabetic wounds

T Xiang, Q Guo, L Jia, T Yin, W Huang… - Advanced …, 2024 - Wiley Online Library
The healing of diabetic wounds is hindered by various factors, including bacterial infection,
macrophage dysfunction, excess proinflammatory cytokines, high levels of reactive oxygen …

Biomaterials: foreign bodies or tuners for the immune response?

E Mariani, G Lisignoli, RM Borzì… - International journal of …, 2019 - mdpi.com
The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

Highly stretchable and biocompatible wrinkled nanoclay‐composite hydrogel with enhanced sensing capability for precise detection of myocardial infarction

J Zhang, S Shen, R Lin, J Huang, C Pu… - Advanced …, 2023 - Wiley Online Library
It is challenging to balance high biocompability with good mechanical–electrical sensing
performance, especially when triggering inflammatory stress response after in vivo …

Designing hydrogels for immunomodulation in cancer therapy and regenerative medicine

Z Zhang, C He, X Chen - Advanced Materials, 2024 - Wiley Online Library
The immune system not only acts as a defense against pathogen and cancer cells, but also
plays an important role in homeostasis and tissue regeneration. Targeting immune systems …

Toward a better regeneration through implant‐mediated immunomodulation: harnessing the immune responses

B Zhang, Y Su, J Zhou, Y Zheng, D Zhu - Advanced science, 2021 - Wiley Online Library
Tissue repair/regeneration, after implantation or injury, involves comprehensive
physiological processes wherein immune responses play a crucial role to enable tissue …

Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

X Cui, C Ma, V Vasudevaraja, J Serrano, J Tong… - Elife, 2020 - elifesciences.org
Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains
unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and …

Rational design of hydrogels for immunomodulation

W Bu, Y Wu, AM Ghaemmaghami… - Regenerative …, 2022 - academic.oup.com
The immune system protects organisms against endogenous and exogenous harm and
plays a key role in tissue development, repair and regeneration. Traditional …