Global Cancer Statistics 2022: the trends projection analysis
BS Chhikara, K Parang - Chemical Biology Letters, 2023 - pubs.thesciencein.org
Cancer is one of the most fatal diseases of recent times that causes several deaths every
year. The disease variations in different parts of the world, the impact of available medical …
year. The disease variations in different parts of the world, the impact of available medical …
Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: biological activity and structural …
Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
Deciphering the mechanism of gilteritinib overcoming lorlatinib resistance to the double mutant I1171N/F1174I in anaplastic lymphoma kinase
S Liang, Q Wang, X Qi, Y Liu, G Li, S Lu… - Frontiers in Cell and …, 2021 - frontiersin.org
Anaplastic lymphoma kinase (ALK) is validated as a therapeutic molecular target in multiple
malignancies, such as non-small cell lung cancer (NSCLC). However, the feasibility of …
malignancies, such as non-small cell lung cancer (NSCLC). However, the feasibility of …
Current insights into the role of BRAF inhibitors in treatment of melanoma
AK Singh, A Kumar, S Thareja… - Anti-Cancer Agents in …, 2023 - benthamdirect.com
Melanomas represent only 4% of all skin cancers, but their mortality rate is more than 50% of
any other skin cancer. Alteration in genetic and environmental factors are the risk factors for …
any other skin cancer. Alteration in genetic and environmental factors are the risk factors for …
Efficient synthesis of chirally enriched 1H-Imidazo [1, 2-b] pyrazole-and 4H-Imidazo [1, 2-b][1, 2, 4] triazole-based bioactive glycohybrids
Carbohydrates, traditionally known for their energy-providing role, have gained significant
attention in drug discovery due to their diverse bioactivities and stereodiversity. However …
attention in drug discovery due to their diverse bioactivities and stereodiversity. However …
Cleaning the molecular machinery of cells via proteostasis, proteolysis and endocytosis selectively, effectively, and precisely: intracellular self-defense and cellular …
R Kumar, BS Chhikara, K Gulia, M Chhillar - Molecular Omics, 2021 - pubs.rsc.org
Network coordinates of cellular processes (proteostasis, proteolysis, and endocytosis), and
molecular chaperones are the key complements in the cell machinery and processes …
molecular chaperones are the key complements in the cell machinery and processes …
Cyclic peptides as protein kinase inhibitors: Structure–activity relationship and molecular modeling
Under-expression or overexpression of protein kinases has been shown to be associated
with unregulated cell signal transduction in cancer cells. Therefore, there is major interest in …
with unregulated cell signal transduction in cancer cells. Therefore, there is major interest in …
Design, synthesis, and antiproliferative activity of benzopyran-4-one-isoxazole hybrid compounds
The biological significance of benzopyran-4-ones as cytotoxic agents against multi-drug
resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays …
resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays …
Design, synthesis, and anticancer screening for repurposed pyrazolo [3, 4-d] pyrimidine derivatives on four mammalian cancer cell lines
The present study reports the synthesis of new purine bioisosteres comprising a pyrazolo [3,
4-d] pyrimidine scaffold linked to mono-, di-, and trimethoxy benzylidene moieties through …
4-d] pyrimidine scaffold linked to mono-, di-, and trimethoxy benzylidene moieties through …
[PDF][PDF] Novel spirooxindole-triazole derivatives: unveiling [3+ 2] cycloaddition reactivity through molecular electron density theory and investigating their potential …
I Shawish, S Alayoubi, A El-Faham, A Aldalbahi… - Frontiers in …, 2024 - frontiersin.org
The development of chemotherapeutic agents demonstrating high efficacy against cancer
cells has been a focal point of research within the scientific community. Consequently …
cells has been a focal point of research within the scientific community. Consequently …