Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently
associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction …

Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells,.
To cope with this threat, cells possess mechanisms that repair the damage and restore …

Cytoplasmic phosphoinositides (PI) are critical regulators of the membrane–cytosol interface
that control a myriad of cellular functions despite their low abundance among phospholipids …

Mitochondrial and lysosomal functions are intimately linked and are critical for cellular
homeostasis, as evidenced by the fact that cellular senescence, aging, and multiple …

Cells respond to lysosomal membrane permeabilization by membrane repair or selective
macroautophagy of damaged lysosomes, termed lysophagy, but it is not fully understood …

Lysosomes are the degradative endpoints of material delivered by endocytosis and
autophagy and are therefore particularly prone to damage. Membrane permeabilization or …

One size does not fit all: Lysosomes exist in biochemically and functionally distinct states |
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The race to uncover fission factors for lysosomal organelles heats up Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …

The endomembrane system consists of organellar membranes in the biosynthetic pathway
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …

Cytotoxic lymphocytes eliminate cancer cells through the release of lytic granules, a
specialized form of secretory lysosomes. This compartment is part of the pleomorphic …