Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation
A family history of atrial fibrillation constitutes a substantial risk of developing the disease,
however, the pathogenesis of this complex disease is poorly understood. We perform whole …
however, the pathogenesis of this complex disease is poorly understood. We perform whole …
Zebrafish approaches enhance the translational research tackle box
MA Pickart, EW Klee - Translational Research, 2014 - Elsevier
During the past few decades, zebrafish (Danio rerio) have been a workhorse for
developmental biology and genetics. Concurrently, zebrafish have proved highly accessible …
developmental biology and genetics. Concurrently, zebrafish have proved highly accessible …
Impaired reorganization of centrosome structure underlies human infantile dilated cardiomyopathy
Background: During cardiomyocyte maturation, the centrosome, which functions as a
microtubule organizing center in cardiomyocytes, undergoes dramatic structural …
microtubule organizing center in cardiomyocytes, undergoes dramatic structural …
PGAP3 Associated with Hyperphosphatasia with Mental Retardation Plays a Novel Role in Brain Morphogenesis and Neuronal Wiring at Early Development
Recessive mutations in Post-GPI attachment to proteins 3 (PGAP3) cause the rare
neurological disorder hyperphosphatasia with mental retardation syndrome 4 type …
neurological disorder hyperphosphatasia with mental retardation syndrome 4 type …
Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart
JT Gafranek, E D'Aniello, P Ravisankar… - Nature …, 2023 - nature.com
How two-chambered hearts in basal vertebrates have evolved from single-chamber hearts
found in ancestral chordates remains unclear. Here, we show that the teleost sinus venosus …
found in ancestral chordates remains unclear. Here, we show that the teleost sinus venosus …
Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening
Rationale: Mutagenesis screening is a powerful genetic tool for probing biological
mechanisms underlying vertebrate development and human diseases. However, the …
mechanisms underlying vertebrate development and human diseases. However, the …
Overexpression of lifeact-GFP disrupts F-actin organization in cardiomyocytes and impairs cardiac function
R Xu, S Du - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Lifeact-GFP is a frequently used molecular probe to study F-actin structure and dynamic
assembly in living cells. In this study, we generated transgenic zebrafish models expressing …
assembly in living cells. In this study, we generated transgenic zebrafish models expressing …
Paxillin and focal adhesion kinase (FAK) regulate cardiac contractility in the zebrafish heart
S Hirth, A Bühler, JB Bührdel, S Rudeck, T Dahme… - PloS one, 2016 - journals.plos.org
An orchestrated interplay of adaptor and signaling proteins at mechano-sensitive sites is
essential to maintain cardiac contractility and when defective leads to heart failure. We …
essential to maintain cardiac contractility and when defective leads to heart failure. We …
Inhibition of TGF-β/Smad3 signaling disrupts cardiomyocyte cell cycle progression and epithelial–mesenchymal transition-like response during ventricle regeneration
Y Peng, W Wang, Y Fang, H Hu, N Chang… - Frontiers in Cell and …, 2021 - frontiersin.org
Unlike mammals, zebrafish can regenerate injured hearts even in the adult stage. Cardiac
regeneration requires the coordination of cardiomyocyte (CM) proliferation and migration …
regeneration requires the coordination of cardiomyocyte (CM) proliferation and migration …
Understanding cardiac sarcomere assembly with zebrafish genetics
Mutations in sarcomere genes have been found in many inheritable human diseases,
including hypertrophic cardiomyopathy. Elucidating the molecular mechanisms of …
including hypertrophic cardiomyopathy. Elucidating the molecular mechanisms of …