Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer's disease (AD). However,
transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally …

In the vertebrate nervous system, myelination of axons for rapid impulse propagation
requires the synthesis of large amounts of lipids and proteins by oligodendrocytes and …

Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial
cells are the most abundant cells in the central nervous system. When spinal cord injury …

Myelin is required for rapid nerve signaling and is emerging as a key driver of CNS plasticity
and disease. How myelin is built and remodeled remains a fundamental question of …

Myelin is essential for rapid nerve signaling and is increasingly found to play important roles
in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as …

NG2 cells, which comprise a cycling population of glial cells, appear in the early phases of
development and are present in the adult central nervous system. When a specific …

Generation of oligodendrocytes in the adult brain enables both adaptive changes in neural
circuits and regeneration of myelin sheaths destroyed by injury, disease, and normal aging …

TDP-43 aggregates in neurons and glia are the defining pathological hallmark of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), raising the …

Neuron–glia communication contributes to the fine-tuning of synaptic functions.
Oligodendrocytes near synapses detect and respond to neuronal activity, but their role in …

The mechanisms by which oligodendroglia modulate CNS angiogenesis remain elusive.
Previous in vitro data suggest that oligodendroglia regulate CNS endothelial cell …