During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of
thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge …

Activation of the intrinsic pathway of coagulation contributes to the pathogenesis of arterial
and venous thrombosis. Critical insights into the involvement of intrinsic pathway factors …

Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild
local inflammation to severe systemic involvement resulting in substantial mortality. Early …

Reactive and clonal neutrophil expansion has been associated with thrombosis, suggesting
that neutrophils play a role in this process. However, although there is no doubt that …

The transition from land to water in whales and dolphins (cetaceans) was accompanied by
remarkable adaptations. To reveal genomic changes that occurred during this transition, we …

Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A
promising solution may be the inhibition of coagulation factor XII (FXII), because its knock …

Abstract C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a
major negative regulator of several biological pathways, including the contact pathway of …

Storage lesion–induced, red cell–derived microvesicles (RBC-MVs) propagate coagulation
by supporting the assembly of the prothrombinase complex. It has also been reported that …

In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2
(ACE2) discovery. This event was a landmark that shaped the way that we see the renin …