VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …

Cancer cells share several properties, high proliferation potential, reprogramed metabolism,
and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key …

Chemotherapy is the major choice for the cancer treatment of early and advanced stages.
However, intrinsic or acquired drug resistance significantly restricts the clinical efficacy of …

Regional lymph node metastasis negatively affects prognosis in colon cancer patients. The
molecular processes leading to regional lymph node metastasis are only partially …

Background Gastric cancer (GC) is the third leading cause of cancer death. Early detection
is a key factor to reduce its mortality. Methods We retrospectively collected pre-and …

Gastric cancer is the second leading cause of cancer-related deaths worldwide. Although
many treatment options exist for patients with gastric tumors, the incidence and mortality rate …

Most of the organs of the digestive tract comprise secretory epithelia that require specialized
molecular machines to achieve their functions. As such anterior gradient (AGR) proteins …

We present previously unknown evidence that the immunoglobulin heavy chain binding
protein BIP/HSPA5, also known as glucose regulated protein (GRP) 78, serving as a pivotal …

Abstract FBXW7 (F-box and WD40 domain protein 7) is a tumor suppressor frequently
inactivated in human cancers. The precise molecular mechanisms by which FBXW7 exerts …

Gastric cancer (GC) is a malignant tumor with high incidence rate and mortality. Due to the
lack of effective diagnostic indicators, most patients are diagnosed in late stage and have a …