This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …

Since the discovery of adrenomedullin in 1993 several hundred papers have been
published regarding the regulation of its secretion and the multiplicity of its actions. It has …

Contraction of smooth muscle is regulated by the cytosolic Ca2+ level ([Ca2+] i) b, and the
sensitivity to Ca2+ of the contractile elements in response to changes in the environment …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

VAN ROSSUM, DU-K. HANISCH AND R. QUIRION. Neuroanatomical localization,
pharmacological characterization and functions of CGRP, related peptides and their …

Objective To examine the cardiovascular, cerebrovascular, and peripheral vascular safety of
erenumab across migraine prevention studies. Methods Vascular adverse events (AEs) and …

Excessive release of inflammatory/pain mediators from peripheral sensory afferents renders
nerve endings hyper-responsive, causing central sensitization and chronic pain. Herein, the …

Peptides released in the spinal cord from the central terminals of nociceptors contribute to
the persistent hyperalgesia that defines the clinical experience of chronic pain. Using …

Vasoactive neuropeptides including substance P and calcitonin gene-related peptide
(CGRP) are localised in sensory nerves which innervate blood vessels. These are the major …

Calcitonin gene‐related peptide (CGRP) is a ubiquitous neuropeptide found at the very
centers of the migraine process, both centrally and peripherally. It has been under careful …