Development and comparative in vitro and in vivo study of BNN27 mucoadhesive liposomes and nanoemulsions for nose-to-brain delivery
Intranasal administration offers an alternative and promising approach for direct nose-to-
brain delivery. Herein, we developed two chitosan (CHT)-coated (and uncoated) …
brain delivery. Herein, we developed two chitosan (CHT)-coated (and uncoated) …
Effects of BNN27, a novel C17-spiroepoxy steroid derivative, on experimental retinal detachment-induced photoreceptor cell death
P Tsoka, H Matsumoto, DE Maidana, K Kataoka… - Scientific Reports, 2018 - nature.com
Retinal detachment (RD) leads to photoreceptor cell death secondary to the physical
separation of the retina from the underlying retinal pigment epithelium. Intensifying …
separation of the retina from the underlying retinal pigment epithelium. Intensifying …
Quantification of BNN27, a novel neuroprotective 17‐spiroepoxy dehydroepiandrosterone derivative in the blood and retina of rodents, after single intraperitoneal …
C Tsika, MN Tzatzarakis, SG Antimisiaris… - Pharmacology …, 2021 - Wiley Online Library
BNN27 is a novel 17‐spiroepoxy derivative of the neurosteroid Dehydroepiandrosterone
with neuroprotective properties. The purpose of this study was the detection and …
with neuroprotective properties. The purpose of this study was the detection and …