2, 5-Diketopiperazines (2, 5-DKPs) are cyclodipeptides obtained by the condensation of two
α-amino acids. They not only abound in nature but are often produced as degradation …

Asymmetric multicomponent reactions involve the preparation of chiral compounds by the
reaction of three or more reagents added simultaneously. This kind of addition and reaction …

Sustainable or green chemistry has established firm ground providing essential design
criteria for the development of efficient chemical syntheses of complex, high added value …

With the recent emergence of combinatorial chemistry and high-speed parallel synthesis for
drug discovery applications, the multi-component reaction (MCR) has seen a resurgence of …

With the emergence of high‐throughput screening in the pharmaceutical industry in the early
1990's, organic chemists were faced with a new challenge: how to prepare large collections …

This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini
three component reaction. After being nearly neglected for many years, now this reaction …

When general and reliable, multicomponent reactions are among the most powerful tools in
modern drug discovery. The principle of chemical ligation of reactive partners (see reaction …

This review describes recent advances in the application of isocyanide-based
multicomponent reactions (IMCRs) in drug discovery and summarizes the various …

Benzodiazepines (BZDs), a diverse class of benzofused seven-membered N-heterocycles,
display essential pharmacological properties and play vital roles in some biochemical …

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has
received much attention. This because they have shown in many cases enhanced …