Under conditions leading to aging and metabolic syndrome, the hypothalamus atypically
undergoes proinflammatory signaling activation leading to a chronic and stable background …

One of the most common lipids in the human body is palmitic acid (PA), a saturated fatty acid
with essential functions in brain cells. PA is used by cells as an energy source, besides …

Insulin resistance (IR), a key component of the metabolic syndrome, precedes the
development of diabetes, cardiovascular disease, and Alzheimer's disease. Its etiological …

Obesity is often associated with cognitive and mood disorders. Recent evidence suggests
that obesity may cause hypothalamic inflammation. Our aim was to investigate the …

There is growing evidence that obesity is associated with brain inflammation in humans,
particularly in the hypothalamus where its presence may disrupt body weight control and …

The hypothalamus plays a major role in the regulation of food intake and energy
expenditure. In the last decade, it was demonstrated that consumption of high-fat diets …

The majority of diabetic patients develop neuropathy and there is an increasing prevalence
of neurodegeneration in the central nervous system (CNS). However, the mechanism …

Hypothalamic dysfunction has emerged as an important mechanism involved in the
development of obesity and its comorbidities, as well as in the process of ageing and age …

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women
of reproductive age. It is a heterogeneous condition characterized by reproductive …

As an important complication of diabetes mellitus, diabetic cardiomyopathy (DCM) is thought
to arise as a result of insulin resistance (IR) in cardiomyocytes. Improving IR in …