[HTML][HTML] Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus
A simple and robust cell culture system is essential for generating authentic SARS-CoV-2
stocks for evaluation of viral pathogenicity, screening of antiviral compounds, and …
stocks for evaluation of viral pathogenicity, screening of antiviral compounds, and …
[HTML][HTML] Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD
Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-
CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral …
CoV-2 variants of concern (VOCs). Understanding NAb epitope-dependent antiviral …
A rapid method for generating infectious SARS-CoV-2 and variants using mutagenesis and circular polymerase extension cloning
BK Kim, WS Choi, JH Jeong, S Oh, JH Park… - Microbiology …, 2023 - Am Soc Microbiol
The appearance of SARS-CoV-2 variants in late 2020 raised alarming global public health
concerns. Despite continued scientific progress, the genetic profiles of these variants bring …
concerns. Despite continued scientific progress, the genetic profiles of these variants bring …
[HTML][HTML] Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens
I Ullah, F Escudie, I Scandale, Z Gilani… - Iscience, 2024 - cell.com
Direct acting antivirals (DAAs) represent critical tools for combating severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that have escaped …
syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that have escaped …
An S1-nanoparticle vaccine protects against SARS-CoV-2 challenge in K18-hACE2 mice
The SARS-CoV-2 pandemic has seen the rapid development and deployment of new
vaccines and vaccine technologies. One of the latter involves the use of nanoparticle or virus …
vaccines and vaccine technologies. One of the latter involves the use of nanoparticle or virus …
A rapid and versatile reverse genetics approach for generating recombinant positive-strand RNA viruses that use IRES-mediated translation
T Tamura, H Yamamoto, S Ogino, Y Morioka… - Journal of …, 2024 - Am Soc Microbiol
Reverse genetics systems have played a central role in developing recombinant viruses for
a wide spectrum of virus research. The circular polymerase extension reaction (CPER) …
a wide spectrum of virus research. The circular polymerase extension reaction (CPER) …
Establishment of a CPER reverse genetics system for Powassan virus defines attenuating NS1 glycosylation sites and an infectious NS1-GFP11 reporter virus
JN Conde, GE Himmler, MC Mladinich, YX Setoh… - Mbio, 2023 - Am Soc Microbiol
Powassan virus (POWV) is an emerging tick-borne Flavivirus that causes lethal encephalitis
and long-term neurologic damage. Currently, there are no POWV therapeutics, licensed …
and long-term neurologic damage. Currently, there are no POWV therapeutics, licensed …
Monitoring SARS-CoV-2 infection using a double reporter-expressing virus
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the highly contagious
agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. An essential …
agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. An essential …