Abstract GPR27, GPR85 and GPR173 constitute a small family of G protein-coupled
receptors (GPCR) that share the distinctive characteristics of being highly conserved …

A new fate of cell surface receptors, cleaved activation in the nucleus, is summarized. The
intracellular domain (ICD) of cell surface receptors, cleaved by enzymes like γ-secretase …

The expression of GPR50 in CSLC and several breast cancer cell lines was assessed by RT-
PCR and online platform (UALCAN, GEPIA, and R2 gene analysis). The role of GPR50 in …

Numerous molecular regulatory mechanisms are involved in the formation of mammalian
oocytes, but many of their key proteins and molecules remain unknown. GPR50, the lone G …

Ischemic-reperfusion injury limits the time window of recanalization therapy in cerebral acute
ischemic stroke (AIS). Brain vessel endothelial cells (BVECs) form the first layer of the blood …

Arrestin-dependent pathways are a central component of G protein-coupled receptor
(GPCRs) signaling. However, the molecular processes regulating arrestin binding are to be …

G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a
critical role in nervous system function by transmitting signals between cells and their …

Gs‐coupled GPCR‐stimulated neuritogenesis in PC12 and NS‐1‐cells depends on
activation of the MAP kinase ERK. Here, we examine changes in ERK activation …

There are> 800 human G protein-coupled receptors (GPCRs). Around half (400) have
sensory functions mediating olfaction, taste, light perception, and pheromone signalling. The …

Small-molecule positive allosteric modulator 1 (SPAM1), which targets pituitary adenylate
cyclase-activating polypeptide receptor 1 (PAC1-R), has been found to have a …