The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Significance: Oxygen is indispensable for aerobic life, but its utilization exposes cells and
tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen …

Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

In recent years, the altitude acclimatization responses elicited by short-term intermittent
exposure to hypoxia have been subject to renewed attention. The main goal of short-term …

Alzheimer's disease (AD) affects not only the central nervous system, but also peripheral
blood cells including neutrophils and platelets, which actively participate in pathogenesis of …

Background Intermittent hypoxia applied at rest or in combination with exercise promotes
multiple beneficial adaptations with regard to performance and health in humans. It was …

It is well-established that different altitude training modalities can improve convective oxygen
(O2) transport capacity and physical fitness of athletes (Millet et al., 2010). Exercising in …

Preconditioning refers to a procedure by which a single noxious stimulus below the
threshold of damage is applied to the tissue in order to increase resistance to the same or …

Oxygen is vital for cellular metabolism; therefore, the hypoxic conditions encountered at high
altitude affect all physiological functions. Acute hypoxia activates the adrenergic system and …