GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

JJ Meier - Nature Reviews Endocrinology, 2012 - nature.com
In healthy humans, the incretin glucagon-like peptide 1 (GLP-1) is secreted after eating and
lowers glucose concentrations by augmenting insulin secretion and suppressing glucagon …

Effects of GLP-1 on appetite and weight

M Shah, A Vella - Reviews in Endocrine and Metabolic Disorders, 2014 - Springer
Abstract Glucagon-like peptide 1 (GLP-1) is a cleavage product of the pre-proglucagon gene
which is expressed in the α-cells of the pancreas, the L-cells of the intestine, and neurons …

The brain, appetite, and obesity

HR Berthoud, C Morrison - Annu. Rev. Psychol., 2008 - annualreviews.org
Food intake and energy expenditure are controlled by complex, redundant, and distributed
neural systems that reflect the fundamental biological importance of adequate nutrient …

Appetite control

K Wynne, S Stanley, B McGowan… - Journal of …, 2005 - joe.bioscientifica.com
Our understanding of the physiological systems that regulate food intake and body weight
has increased immensely over the past decade. Brain centres, including the hypothalamus …

Obesity: pathophysiology and intervention

Y Zhang, J Liu, J Yao, G Ji, L Qian, J Wang, G Zhang… - Nutrients, 2014 - mdpi.com
Obesity presents a major health hazard of the 21st century. It promotes co-morbid diseases
such as heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and …

Peptides and food intake

C Sobrino Crespo, A Perianes Cachero… - Frontiers in …, 2014 - frontiersin.org
The mechanisms for controlling food intake involve mainly an interplay between gut, brain,
and adipose tissue (AT), among the major organs. Parasympathetic, sympathetic, and other …

The role of gut hormones and the hypothalamus in appetite regulation

K Suzuki, KA Simpson, JS Minnion, JC Shillito… - Endocrine …, 2010 - jstage.jst.go.jp
The World Health Organisation has estimated that by 2015 approximately 2.3 billion adults
will be overweight and more than 700 million obese. Obesity is associated with an increased …

Acute exercise and hormones related to appetite regulation: a meta-analysis

MM Schubert, S Sabapathy, M Leveritt, B Desbrow - Sports medicine, 2014 - Springer
Background Understanding of the impact of an acute bout of exercise on hormones involved
in appetite regulation may provide insight into some of the mechanisms that regulate energy …

Obesity and appetite control

K Suzuki, CN Jayasena… - Journal of Diabetes …, 2012 - Wiley Online Library
Obesity is one of the major challenges to human health worldwide; however, there are
currently no effective pharmacological interventions for obesity. Recent studies have …

Role of neuropeptides in appetite regulation and obesity–a review

S Arora - Neuropeptides, 2006 - Elsevier
Obesity represents the most prevalent nutritional problem worldwide which in the long run
predisposes to development of diabetes mellitus, hypertension, endometrial carcinoma …