Identification and confirmation of bioactive small‐molecule targets is a crucial, often decisive
step both in academic and pharmaceutical research. Through the development and …

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling
pathway that regulates a wide variety of stimulated cellular processes, including mainly …

Kinase inhibitors have limited success in cancer treatment because tumors circumvent their
action. Using a quantitative proteomics approach, we assessed kinome activity in response …

Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic
disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects …

The salt-inducible kinases, SIK1, SIK2 and SIK3, most closely resemble the AMP-activated
protein kinase (AMPK) and other AMPK-related kinases, and like these family members they …

The human protein kinome comprises 535 proteins that, with the exception of approximately
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

The primary purpose of PHOSIDA (http://www. phosida. com) is to manage posttranslational
modification sites of various species ranging from bacteria to human. Since its last report …

Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl
transfer, termed pseudokinases, have emerged as important signalling domains across all …

The transition element zinc, which has recently been identified as an intracellular second
messenger, has been implicated in various signaling pathways, including those leading to …