Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …

Compounds acting on multiple targets are critical to combating antimalarial drug resistance.
Here, we report that the human “mammalian target of rapamycin”(mTOR) inhibitor …

Structure–activity relationship studies of 2, 8-disubstituted-1, 5-naphthyridines, previously
reported as potent inhibitors of Plasmodium falciparum (Pf) phosphatidylinositol-4-kinase β …

Malaria is a devastating disease caused by Plasmodium parasites, resulting in
approximately 435000 deaths in 2018. The impact of malaria is compounded by the …

Abstract Phosphatidylinositol 4-phosphate (PI4P) is a membrane glycerophospholipid and a
major regulator of the characteristic appearance of the Golgi complex as well as its vesicular …

Plasmodium spp. parasites that cause malaria disease remain a significant global-health
burden. With the spread of parasites resistant to artemisinin combination therapies in …

Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …

ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and
transmission control measures led to a decrease in the global malaria burden over the …