Chemical reporters for bacterial glycans: development and applications

N Banahene, HW Kavunja, BM Swarts - Chemical reviews, 2021 - ACS Publications
Bacteria possess an extraordinary repertoire of cell envelope glycans that have critical
physiological functions. Pathogenic bacteria have glycans that are essential for growth and …

Exploration of the sialic acid world

R Schauer, JP Kamerling - Advances in carbohydrate chemistry and …, 2018 - Elsevier
Sialic acids are cytoprotectors, mainly localized on the surface of cell membranes with
multiple and outstanding cell biological functions. The history of their structural analysis …

Biological roles of glycans

A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Mucins: a biologically relevant glycan barrier in mucosal protection

AP Corfield - Biochimica et Biophysica Acta (BBA)-General Subjects, 2015 - Elsevier
Background The mucins found as components of mucus gel layers at mucosal surfaces
throughout the body play roles in protection as part of the defensive barrier on an organ and …

Multifarious roles of sialic acids in immunity

A Varki, P Gagneux - Annals of the New York Academy of …, 2012 - Wiley Online Library
Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

[HTML][HTML] Sialic acids and other nonulosonic acids

AL Lewis, X Chen, RL Schnaar… - Essentials of Glycobiology …, 2022 - ncbi.nlm.nih.gov
Sialic acids (Sias) are abundant on vertebrate glycoproteins, glycolipids, and milk
oligosaccharides, as well as on some microbial surface glycans, mediating diverse …

[HTML][HTML] Sialic acids and other nonulosonic acids

A Varki, RL Schnaar, R Schauer - 2017 - europepmc.org
Sialic acids are abundant on vertebrate glycoproteins and have diverse functional roles.
Originally discovered within the Deuterostome lineage of animals and associated microbes …

Advances in the biology and chemistry of sialic acids

X Chen, A Varki - ACS chemical biology, 2010 - ACS Publications
Sialic acids are a subset of nonulosonic acids, which are nine-carbon α-keto aldonic acids.
Natural existing sialic acid-containing structures are presented in different sialic acid forms …

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

D Ghaderi, M Zhang, N Hurtado-Ziola… - Biotechnology and …, 2012 - Taylor & Francis
One of the fastest growing fields in the pharmaceutical industry is the market for therapeutic
glycoproteins. Today, these molecules play a major role in the treatment of various diseases …

Sialic acid O-acetylation: From biosynthesis to roles in health and disease

EA Visser, SJ Moons, SBPE Timmermans… - Journal of Biological …, 2021 - ASBMB
Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of
vertebrates as well as cells of certain types of invertebrates and bacteria. The nine-carbon …