ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
AN Blackford, SP Jackson - Molecular cell, 2017 - cell.com
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
Transcriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer
Y Bao, L Wang, L Shi, F Yun, X Liu, Y Chen… - Cellular & molecular …, 2019 - Springer
Background Exploration of the genes with abnormal expression during the development of
breast cancer is essential to provide a deeper understanding of the mechanisms involved …
breast cancer is essential to provide a deeper understanding of the mechanisms involved …
ATM activation by oxidative stress
The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …
Why do viruses cause cancer? Highlights of the first century of human tumour virology
The year 2011 marks the centenary of Francis Peyton Rous's landmark experiments on an
avian cancer virus. Since then, seven human viruses have been found to cause 10–15% of …
avian cancer virus. Since then, seven human viruses have been found to cause 10–15% of …
The MRE11 complex: starting from the ends
TH Stracker, JHJ Petrini - Nature reviews Molecular cell biology, 2011 - nature.com
The maintenance of genome stability depends on the DNA damage response (DDR), which
is a functional network comprising signal transduction, cell cycle regulation and DNA repair …
is a functional network comprising signal transduction, cell cycle regulation and DNA repair …
[HTML][HTML] The MRN complex in double-strand break repair and telomere maintenance
BJ Lamarche, NI Orazio, MD Weitzman - FEBS letters, 2010 - Elsevier
Genomes are subject to constant threat by damaging agents that generate DNA double-
strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA …
strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA …
[HTML][HTML] Requirement of the MRN complex for ATM activation by DNA damage
T Uziel, Y Lerenthal, L Moyal, Y Andegeko… - The EMBO …, 2003 - embopress.org
The ATM protein kinase is a primary activator of the cellular response to DNA double‐strand
breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in …
breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in …
ATM-and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
A Jazayeri, J Falck, C Lukas, J Bartek, GCM Smith… - Nature cell …, 2006 - nature.com
It is generally thought that the DNA-damage checkpoint kinases, ataxia-telangiectasia
mutated (ATM) and ATM-and Rad3-related (ATR), work independently of one another. Here …
mutated (ATM) and ATM-and Rad3-related (ATR), work independently of one another. Here …
[HTML][HTML] Adenoviruses as vaccine vectors
N Tatsis, HCJ Ertl - Molecular Therapy, 2004 - cell.com
Adenoviruses have transitioned from tools for gene replacement therapy to bona fide
vaccine delivery vehicles. They are attractive vaccine vectors as they induce both innate and …
vaccine delivery vehicles. They are attractive vaccine vectors as they induce both innate and …