Therapeutic potential of TAAR1 agonists in schizophrenia: evidence from preclinical models and clinical studies
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …
[HTML][HTML] Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges
The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
Methamphetamine: effects on the brain, gut and immune system
Methamphetamine (METH) is a powerful central nervous system stimulant which elevates
mood, alertness, energy levels and concentration in the short-term. However, chronic use …
mood, alertness, energy levels and concentration in the short-term. However, chronic use …
Trace amines and the trace amine-associated receptor 1: pharmacology, neurochemistry, and clinical implications
Y Pei, A Asif-Malik, JJ Canales - Frontiers in neuroscience, 2016 - frontiersin.org
Biogenic amines are a collection of endogenous molecules that play pivotal roles as
neurotransmitters and hormones. In addition to the “classical” biogenic amines resulting …
neurotransmitters and hormones. In addition to the “classical” biogenic amines resulting …
Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains
SM Underhill, PD Hullihen, J Chen… - Molecular …, 2021 - nature.com
The extensive use of amphetamines to treat attention deficit hyperactivity disorders in
children provides a compelling rationale for understanding the mechanisms of action of …
children provides a compelling rationale for understanding the mechanisms of action of …
TAAR1 as an emerging target for the treatment of psychiatric disorders
J Liu, R Wu, JX Li - Pharmacology & Therapeutics, 2024 - Elsevier
Trace amines, a group of amines expressed at the nanomolar level in the mammalian brain,
can modulate monoamine transmission. The discovery of and the functional research on the …
can modulate monoamine transmission. The discovery of and the functional research on the …
Pharmacotherapeutic agents in the treatment of methamphetamine dependence
KC Morley, JL Cornish, A Faingold… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Methamphetamine use is a serious public health concern in many countries
and is second to cannabis as the most widely abused illicit drug in the world. Effective …
and is second to cannabis as the most widely abused illicit drug in the world. Effective …
Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases
MD Schwartz, JJ Canales, R Zucchi… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: The trace amines, endogenous amines closely related to the biogenic amine
neurotransmitters, have been known to exert physiological and neurological effects for …
neurotransmitters, have been known to exert physiological and neurological effects for …
Trace amine-associated receptor 1 regulation of methamphetamine intake and related traits
JH Harkness, X Shi, A Janowsky… - …, 2015 - nature.com
Continued methamphetamine (MA) use is dependent on a positive MA experience and is
likely attenuated by sensitivity to the aversive effects of MA. Bidirectional selective breeding …
likely attenuated by sensitivity to the aversive effects of MA. Bidirectional selective breeding …
TAAR agonists
Z Xu, Q Li - Cellular and molecular neurobiology, 2020 - Springer
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors
(GPCRs) that are evolutionarily conserved in vertebrates. The first discovered TAAR1 is …
(GPCRs) that are evolutionarily conserved in vertebrates. The first discovered TAAR1 is …