The cell cycle is the series of events that take place in a cell, which drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the …

The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated
protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells …

The extracellular-regulated kinases ERK1 and ERK2 are evolutionarily conserved,
ubiquitous serine–threonine kinases that are involved in regulating cellular signaling in both …

A large number of serum growth factors stimulate cellular mitogenesis by interaction with a
family of cell-surface receptors that possess an intrinsic, ligand-sensitive, protein tyrosine …

Protein tyrosine phosphatases (PTPs) represent a diverse family of enzymes that exist as
integral membrane and nonreceptor forms. The PTPs, with specific activities in vitro 10 to …

The MAP kinases, discovered approximately 20 years ago, together with their immediate
upstream regulators, are among the most highly studied signal transduction molecules. This …

pp42, a low-abundance 42-kDa protein, becomes transiently phosphorylated on tyrosine
after stimulation of fibroblasts by a variety of mitogens, including epidermal growth factor …

An hepatic protein kinase that phosphorylates microtubule-associated protein 2 (MAP-2) on
Ser/Thr residues is markedly activated after intraperitoneal injection of cycloheximide in the …

plasma shows a peak 4–6 kpc from the galactic centre. The Page 1 NATURE VOL. 312 20/27
DECEMBER 1984 this dense plasma. Although in our models we have assumed that scattering …

Exposure of 3T3-L1 cells to insulin stimulates a soluble, serine (threonine)-specific protein
kinase that phosphorylates microtubule-associated protein 2 (MAP-2) in vitro. The enzyme …