The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in
Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional …

Carey, Hannah V., Matthew T. Andrews, and Sandra L. Martin. Mammalian Hibernation:
Cellular and Molecular Responses to Depressed Metabolism and Low Temperature. Physiol …

The early observations on the rate-of-living theory by Max Rubner and the report by
Gershman that oxygen free radicals exist in vivo culminated in the seminal proposal in the …

Autophagy is involved with the turnover of intracellular components and the management of
stress responses. Genetic studies in mice have shown that suppression of neuronal …

It is widely appreciated that larvae of the nematode Caenorhabditis elegans arrest
development by forming dauer larvae in response to multiple unfavorable environmental …

Understanding how nerves regenerate is an important step towards developing treatments
for human neurological disease, but investigation has so far been limited to complex …

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

We have developed Textpresso, a new text-mining system for scientific literature whose
capabilities go far beyond those of a simple keyword search engine. Textpresso's two major …

Caenorhabditis elegans is an important model organism with many useful features,
including rapid development and aging, easy cultivation, and genetic tractability. Survival …