Engineered in vitro disease models
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …
human disease or to develop new and improved therapies or diagnostics. Although great …
Perspectives for clinical use of engineered human host defense antimicrobial peptides
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of
death worldwide. The emergence of drug-resistance mechanisms, especially among …
death worldwide. The emergence of drug-resistance mechanisms, especially among …
Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1
Background Global resurgence of dengue virus infections in many of the tropical and
subtropical countries is a major concern. Therefore, there is an urgent need for the …
subtropical countries is a major concern. Therefore, there is an urgent need for the …
A guide to polarized airway epithelial models for studies of host–pathogen interactions
Mammalian lungs are organs exhibiting the cellular and spatial complexity required for gas
exchange to support life. The respiratory epithelium internally lining the airways is …
exchange to support life. The respiratory epithelium internally lining the airways is …
The response of human nasal and bronchial organotypic tissue cultures to repeated whole cigarette smoke exposure
M Talikka, R Kostadinova, Y Xiang… - International …, 2014 - journals.sagepub.com
Exposure to cigarette smoke (CS) is linked to the development of respiratory diseases, and
there is a need to understand the mechanisms whereby CS causes damage. Although …
there is a need to understand the mechanisms whereby CS causes damage. Although …
Inhibition of SARS-CoV-2 3CL protease by the anti-viral chimeric protein RetroMAD1
LC Chan, AS Mat Yassim, AAH Ahmad Fuaad… - Scientific Reports, 2023 - nature.com
COVID-19 results from SARS-CoV-2, which mutates frequently, challenging current
treatments. Therefore, it is critical to develop new therapeutic drugs against this disease …
treatments. Therefore, it is critical to develop new therapeutic drugs against this disease …
Exploring alternative strategies for Staphylococcus aureus nasal decolonization: insights from preclinical studies
J Jayakumar, V Vinod, L Biswas… - Letters in Applied …, 2023 - academic.oup.com
Nasal decolonization of Staphylococcus aureus with the antibiotic mupirocin is a common
clinical practice before complex surgical procedures, to prevent hospital acquired infections …
clinical practice before complex surgical procedures, to prevent hospital acquired infections …
Identification of nasal Gammaproteobacteria with potent activity against Staphylococcus aureus: novel insights into the “noncarrier” state
Staphylococcus aureus nasal carriage provides the bacterial reservoir for opportunistic
infection. In comparing the nasal microbiomes of culture-defined persistent S. aureus …
infection. In comparing the nasal microbiomes of culture-defined persistent S. aureus …
Cessation from smoking improves innate host defense and clearance of experimentally inoculated nasal Staphylococcus aureus
AL Cole, M Schmidt-Owens, AC Beavis… - Infection and …, 2018 - Am Soc Microbiol
Staphylococcus aureus nasal carriage is transient in most humans and usually benign, but
dissemination of S. aureus to extranasal sites causes the majority of clinical infections, and …
dissemination of S. aureus to extranasal sites causes the majority of clinical infections, and …
A hybrid cationic peptide composed of human β-defensin-1 and humanized Θ-defensin sequences exhibits salt-resistant antimicrobial activity
S Olli, R Nagaraj, SR Motukupally - Antimicrobial Agents and …, 2015 - Am Soc Microbiol
We have designed a hybrid peptide by combining sequences of human β-defensin-1 (HBD-
1) and θ-defensin, in an attempt to generate a molecule that combines the diversity in …
1) and θ-defensin, in an attempt to generate a molecule that combines the diversity in …