Introduction Interindividual differences in drug response are a frequent clinical challenge
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …

Introduction: Efavirenz commonly causes early neuropsychiatric side effects, but tolerance
develops in most patients. There is emerging evidence that efavirenz use may damage …

Objectives We evaluated the importance of ethnicity and pharmacogenetic variations in
determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two …

Background HIV infection, anti-tuberculosis and efavirenz therapy are associated with
neuropsychological effects. We evaluated the influence of rifampicin cotreatment, efavirenz …

Aims Genetic factors, notably CYP2B6 516G→ T [rs3745274] and 983T→ C [rs28399499],
explain much of the interindividual variability in efavirenz pharmacokinetics, but data from …

Effective interventions and treatments for complex diseases have been implemented
globally, however, coverage in Africa has been comparatively lower due to lack of capacity …

Methods HIV/AIDS patients were recruited from Themba Lethu Clinic, at Helen Joseph
Hospital, Johannesburg. Blood samples for plasma drug levels and DNA extraction were …

Background Due to the unparalleled genetic diversity of its peoples, Africa is attracting
growing research attention. Several African populations have been assessed in global …

Introduction: Africa harbors a disproportionate burden of disease when taking into account
the triple challenge caused by HIV/AIDS, tuberculosis (TB) and malaria, against a backdrop …

We investigated the influence of efavirenz (EFV)-or nevirapine (NVP)-based antiretroviral
therapy (ART) on lumefantrine plasma exposure in HIV-malaria-coinfected patients and …