Tumor-infiltrating lymphocytes in the immunotherapy era

ST Paijens, A Vledder, M de Bruyn… - Cellular & molecular …, 2021 - nature.com
The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …

Deep learning in cancer pathology: a new generation of clinical biomarkers

A Echle, NT Rindtorff, TJ Brinker, T Luedde… - British journal of …, 2021 - nature.com
Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers.
However, the growing number of these complex biomarkers tends to increase the cost and …

Multimodal co-attention transformer for survival prediction in gigapixel whole slide images

RJ Chen, MY Lu, WH Weng, TY Chen… - Proceedings of the …, 2021 - openaccess.thecvf.com
Survival outcome prediction is a challenging weakly-supervised and ordinal regression task
in computational pathology that involves modeling complex interactions within the tumor …

Vision Transformers in medical computer vision—A contemplative retrospection

A Parvaiz, MA Khalid, R Zafar, H Ameer, M Ali… - … Applications of Artificial …, 2023 - Elsevier
Abstract Vision Transformers (ViTs), with the magnificent potential to unravel the information
contained within images, have evolved as one of the most contemporary and dominant …

Deep neural network models for computational histopathology: A survey

CL Srinidhi, O Ciga, AL Martel - Medical image analysis, 2021 - Elsevier
Histopathological images contain rich phenotypic information that can be used to monitor
underlying mechanisms contributing to disease progression and patient survival outcomes …

Pan-cancer integrative histology-genomic analysis via multimodal deep learning

RJ Chen, MY Lu, DFK Williamson, TY Chen, J Lipkova… - Cancer Cell, 2022 - cell.com
The rapidly emerging field of computational pathology has demonstrated promise in
developing objective prognostic models from histology images. However, most prognostic …

Artificial intelligence for digital and computational pathology

AH Song, G Jaume, DFK Williamson, MY Lu… - Nature Reviews …, 2023 - nature.com
Advances in digitizing tissue slides and the fast-paced progress in artificial intelligence,
including deep learning, have boosted the field of computational pathology. This field holds …

Whole slide images are 2d point clouds: Context-aware survival prediction using patch-based graph convolutional networks

RJ Chen, MY Lu, M Shaban, C Chen, TY Chen… - … Image Computing and …, 2021 - Springer
Cancer prognostication is a challenging task in computational pathology that requires
context-aware representations of histology features to adequately infer patient survival …

Deep learning supported discovery of biomarkers for clinical prognosis of liver cancer

J Liang, W Zhang, J Yang, M Wu, Q Dai, H Yin… - Nature Machine …, 2023 - nature.com
Tissue biomarkers are crucial for cancer diagnosis, prognosis assessment and treatment
planning. However, there are few known biomarkers that are robust enough to show true …

A novel lightweight deep convolutional neural network for early detection of oral cancer

F Jubair, O Al‐karadsheh, D Malamos… - Oral …, 2022 - Wiley Online Library
Objectives To develop a lightweight deep convolutional neural network (CNN) for binary
classification of oral lesions into benign and malignant or potentially malignant using …