Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …

Cancer growth and progression are associated with immune suppression. Cancer cells
have the ability to activate different immune checkpoint pathways that harbor …

Immune checkpoint inhibitors, including antibodies that block programmed cell death protein-
1 (PD-1) and PD-L1, have transformed the management of many cancers. However, the …

The immune microenvironment of hepatocellular carcinoma (HCC) is poorly characterized.
Combining two single-cell RNA sequencing technologies, we produced transcriptomes of …

Advances in immunotherapy have led to durable and long‐term benefits in a subset of
patients across a number of solid tumor types. Understanding of the subsets of patients that …

Abstract Background Tumor-associated macrophages (TAMs), which form a large part of the
tumor microenvironment, are normally regulated by metabolic reprogramming. However, the …

Objectives The interaction between the immune system and tumor cells is an important
feature for the prognosis and treatment of cancer. Multiplex immunohistochemistry (mIHC) …

Tumors can be divided into 'hot'(T cell inflamed) or 'cold'(T cell noninflamed) according to the
presence of immune cells. In this review, we discuss variables that influence T cell migration …

Immune checkpoint blockade is promising for treating non-small-cell lung cancer (NSCLC).
We used multipanel markers to predict the response to immune checkpoint inhibitors (ICIs) …

Therapies targeting immune checkpoint molecules CTLA-4 and PD-1/PD-L1 have advanced
the field of cancer immunotherapy. New mAbs targeting different immune checkpoint …