Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Acetylation is a key post-translational modification (PTM) involved in the regulation of both
histone and non-histone proteins. It controls cellular processes such as DNA transcription …

Prion diseases are transmissible spongiform encephalopathies (TSEs) caused by a
conformational conversion of the native cellular prion protein (PrPC) to an abnormal …

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the
exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely …

The transactive response DNA-binding protein (TARDBP/TDP-43) influences the processing
of diverse transcripts, including that of histone deacetylase 6 (HDAC6). Here, we assessed …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder
characterized by progressive axonopathy, jointly leading to the dying back of the motor …

Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron disease characterized by
sustained loss of neuromuscular junctions, degenerating corticospinal motoneurons and …

Abstract Background Histone deacetylase 6 (HDAC6) inhibitor CAY10603 has been
identified as a potential therapeutic agent for the treatment of diabetic kidney disease (DKD) …

Background Despite the discovery of familial cases with mutations in Cu/Zn-superoxide
dismutase (SOD1), Guanine nucleotide exchange C9orf72, TAR DNA-binding protein 43 …

Post-translational modifications (PTMs) of proteins define the molecular complexity of our
cells. Through mechanisms such as covalent modifications of proteins, PTMs change the …