Background Glucose regulating protein 78 (GRP78) is one member of the Heat Shock
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …

Ischemia-reperfusion injury (I/R injury) is a common feature of ischemic stroke which occurs
when blood supply is restored after a period of ischemia. Although stroke is an important …

Ochratoxin A (OTA), a secondary fungal metabolite with nephrotoxicity, is widespread in
numerous kinds of feeds and foodstuffs. Ursolic acid (UA), a water-insoluble pentacyclic …

The endoplasmic reticulum (ER) is the site of production and folding of secreted, membrane
bound and some organelle targeted proteins. Accumulation of misfolded or unfolded …

Background The incidence of coronary heart disease (CHD) in premenopausal women is
significantly lower than that of men of the same age, suggesting protective roles of estrogen …

Endoplasmic reticulum (ER) is a subcellular organelle involved in protein folding and
processing. ER stress constitutes a cellular process characterized by accumulation of …

In recent years, ongoing interest in ischemic brain injury research has provided data
showing that ischemic episodes are involved in the development of Alzheimer's disease-like …

The steroidal drug Tibolone is used for the treatment of climacteric symptoms and
osteoporosis in post-menopausal women. Although Tibolone has been shown to exert …

Pulmonary dysfunction is tightly associated with cough variant asthma (CVA), a respiratory
damage disease. Suhuang antitussive capsule (Suhuang), one of traditional Chinese patent …

Voltage-gated calcium channels are key regulators of brain function, and their dysfunction
has been associated with multiple conditions and neurodegenerative diseases because …