For the planning of an organic synthesis route, the disconnection approach guided by
retrosynthetic analysis of possible intermediates and the chemical reactions involved, back …

The acylation of α-substituted carbanion-type reagents (MCR 1 R 2 X; X= halogen, OR, SR,
NR 3 R 4, SeR, etc.) with Weinreb amides constitutes a highly versatile and flexible …

The development of a continuous flow process for the multistep synthesis of α-halo ketones
starting from N-protected amino acids is described. The obtained α-halo ketones are chiral …

The transfer of a reactive nucleophilic CH2X unit into a preformed bond enables the
introduction of a fragment featuring the exact and desired degree of functionalization …

The addition of lithium carbenoids to isocyanates provides a versatile access to N-
substituted 2-haloacetamides: the reaction tolerates the presence of variously functionalized …

Abstract β, γ‐Unsaturated aldehydes with all‐carbon quaternary or tertiary α‐centers were
rapidly assembled from ketones through a unique synthetic operation consisting of 1) C1 …

Abstract α‐Halomethyllithium carbenoids are useful homologating reagents which–reacting
under proper reaction conditions as carbanions–enable the installation via nucleophilic …

An efficient, chemoselective homologation of disulfides and diselenides to the
corresponding dithio-and diselenoacetals has been developed via the addition of …

This work demonstrates that the accurate control of the reaction parameters realized within
microreactor systems allowed for a taming of the reactivity of thermally unstable …

The recent increase in the number of AIDS patients has become one of the world's greatest
social problems. According to the estimation by UNAIDS in 2004, 1 about 40 million people …