The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases
DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation …

Colorectal cancer (CRC) that demonstrates microsatellite instability (MSI) is caused by either
germline mismatch repair (MMR) gene mutations, or 'sporadic'somatic tumour MLH1 …

Lynch syndrome patients are susceptible to colorectal and endometrial cancers owing to
inactivating germline mutations in mismatch repair genes, including MSH2 (ref.). Here we …

The utility of immunohistochemical detection of DNA mismatch repair (MMR) protein in
screening colorectal tumors for hereditary nonpolyposis colorectal cancer (HNPCC) …

It was shown that Lynch syndrome can be caused by germline hypermethylation of the
MLH1 and MSH2 promoters. Furthermore, it has been demonstrated very recently that …

Lynch syndrome, familial adenomatous polyposis, and Mut Y homolog (MYH)-associated
polyposis are three major known types of inherited colorectal cancer, which accounts for up …

The development of colorectal cancer (CRC) can be influenced by genetic factors in both
familial cases and sporadic cases. Familial CRC has been associated with genetic changes …

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome
characterised by a predisposition to early onset colorectal, endometrial and other cancers …

Lynch syndrome is an autosomal dominant cancer predisposition syndrome characterized
by loss of function of DNA mismatch repair enzyme MLH1, MSH2, MSH6, or PMS2 …

Background and aims Lynch syndrome (LS) patients have DNA mismatch repair deficiency
and up to 80% lifetime risk of colorectal cancer (CRC). Screening of mutation carriers …