Utilization of polymers as biomaterials has greatly impacted the advancement of modern
medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant …

As dense connective tissues connecting bone to muscle and bone to bone, respectively,
tendon and ligament (T/L) arise from the somitic mesoderm, originating in a recently …

Abstract This Progress Report reviews recent progress in applying electrospun nanofibers to
the emerging field of regenerative medicine. It begins with a brief introduction to …

Gradient scaffolds are isotropic/anisotropic three-dimensional structures with gradual
transitions in geometry, density, porosity, stiffness, etc., that mimic the biological extracellular …

Bringing to life the fascinating structures and unique mechanics of natural and biomedical
cellular materials, this book is an expert guide to the subject for graduates and researchers …

The integration of tendon into bone occurs at a specialized interface known as the enthesis.
The fibrous tendon to bone enthesis is established through a structurally continuous …

Engineering synthetic scaffolds to repair and regenerate ruptured native tendon and
ligament (T/L) tissues is a significant engineering challenge due to the need to satisfy both …

Extracellular matrix fibers (ECM) such as collagen, elastin, and keratin provide biological
and physical support for cell attachment, proliferation, migration, differentiation and …

Ligaments and tendons are fibrous tissues with poor vascularity and limited regeneration
capacity. Currently, a ligament/tendon injury often require a surgical procedure using auto-or …

Regeneration of injured tendon and ligament (T&L) remains a clinical challenge due to their
poor intrinsic healing capacity. Tissue engineering provides a promising alternative …