Interconnections between inflammageing and immunosenescence during ageing

T Teissier, E Boulanger, LS Cox - Cells, 2022 - mdpi.com
Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

[HTML][HTML] Targeting immune dysfunction in aging

S Borgoni, KS Kudryashova, K Burka… - Ageing research …, 2021 - Elsevier
Human aging is a multifactorial phenomenon that affects numerous organ systems and
cellular processes, with the immune system being one of the most dysregulated …

A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes

Q Luo, VB Dwaraka, Q Chen, H Tong, T Zhu, K Seale… - Genome Medicine, 2023 - Springer
Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …

Gut microbiota and serum metabolic signatures of high-Fat-Induced bone loss in mice

L Lu, M Tang, J Li, Y Xie, Y Li, J Xie, L Zhou… - Frontiers in cellular …, 2021 - frontiersin.org
Background Accumulating evidence indicates that high-fat diet (HFD) is a controllable risk
factor for osteoporosis, but the underlying mechanism remains to be elucidated. As a …

Rebalancing the unbalanced aged immune system–A special focus on zinc

BR Baarz, L Rink - Ageing research reviews, 2022 - Elsevier
Nowadays, aging is understood as a dynamic and multifaceted dysregulation process that
spares almost no human organ or cell. The immune system being among the most affected …

Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components

R Sharma, B Diwan, A Sharma, JM Witkowski - Biogerontology, 2022 - Springer
Immunological aging is strongly associated with the observable deleterious effects of human
aging. Our understanding of the causes, effects, and therapeutics of aging immune cells has …

Non-genomic hallmarks of aging—The Review

D Holmannova, P Borsky, H Parova… - International Journal of …, 2023 - mdpi.com
Aging is a natural, gradual, and inevitable process associated with a series of changes at
the molecular, cellular, and tissue levels that can lead to an increased risk of many diseases …

Grape seed extract prevents oestrogen deficiency‐induced bone loss by modulating the gut microbiota and metabolites

L Lu, J Li, L Liu, C Wang, Y Xie, X Yu… - Microbial …, 2024 - Wiley Online Library
Proanthocyanidin‐rich grape seed extract (GSE) has been shown to have the potential to
protect bones, although the underlying mechanism remains unknown. The current study …

Alterations in metabolic pathways: a bridge between aging and weaker innate immune response

Z Saleh, S Mirzazadeh, F Mirzaei, K Heidarnejad… - Frontiers in …, 2024 - frontiersin.org
Aging is a time-dependent progressive physiological process, which results in impaired
immune system function. Age-related changes in immune function increase the susceptibility …

Exopolysaccharide Producing Bifidobacterium animalis subsp. lactis Strains Modify the Intestinal Microbiota and the Plasmatic Cytokine Levels of BALB/c Mice …

C Sabater, N Molinero-García, N Castro-Bravo… - Frontiers in …, 2020 - frontiersin.org
Bacteria-host interactions are mediated by different microbial associated molecular patterns
which are most often surface structures such as, among others, exopolysaccharides (EPSs) …