Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

Systemic inflammation can be triggered by infection, surgery, trauma or burns. During
systemic inflammation, an overshooting immune response induces tissue damage resulting …

Chimeric antigen receptor (CAR) T cells provide new therapeutic options for patients with
relapsed/refractory hematologic malignancies. However, neurotoxicity is a frequent, and …

Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an
overwhelming host response to infection resulting in organ failure. The endothelium is an …

Sepsis is a dysregulated systemic reaction to a common infection, that can cause life-
threatening organ dysfunction. Over the last decade, the mortality rate of patients with sepsis …

Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating
leukocytes. While this scarcity long hampered basophil studies, innovations during the past …

Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum
enables their sequestration via attachment to the microvasculature. This artificially increases …

The vascular endothelium is crucial for the maintenance of vascular homeostasis. Moreover,
in sepsis, endothelial cells can acquire new properties and actively participate in the host's …

Ischemic stroke (IS) is a cerebrovascular disease causing high rates of disability and fatality.
In recent years, the concept of the neurovascular unit (NVU) has been accepted by an …