Our skin protects us from external threats including ultraviolet radiation, pathogens and
chemicals, and prevents excessive trans-epidermal water loss. These varied activities are …

Scarring is caused by excessive medical treatment in the tissue remodeling stage; hence,
the need for medication is not constant throughout the stage of burn recovery. In this study …

The acid mantle concept refers to the buffer system located in the upper stratum corneum of
the skin. By sustaining an acidic environment, the acid mantle contributes to the regulation of …

Ionic liquids (ILs) have great potential to facilitate transdermal and topical drug delivery.
Here, we investigated the mechanism of action of amphiphilic ILs 1-methyl-3 …

The lipids in the mammalian stratum corneum (SC) adopt an unusually rigid arrangement to
form a vital barrier preventing water loss and harmful environmental impacts. Just above the …

Desulfation of cholesterol sulfate (CholS) to cholesterol (Chol) is an important event in
epidermal homeostasis and necessary for stratum corneum (SC) barrier function. The …

The stratum corneum is the outermost skin layer with a vital role in skin barrier function. It is
comprised of dead keratinocytes (corneocytes) and is known to maintain its thickness by …

Eugenol is a major phenolic component derived from clove oil with potential medical
applications. Of particular interest, it has been used as a therapeutic agent in topical …

Introduction: Skin microbiome and skin physiology are important indicators of the epidermal
homeostasis status. Stress models can reveal pathological conditions and modulating …

When the ancestors of men moved from aquatic habitats to the drylands, their evolutionary
strategy to restrict water loss is to seal the skin surface with lipids. It is unknown how these …