Genetics of diabetes mellitus and diabetes complications
Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
Heart disease and stroke statistics—2018 update: a report from the American Heart Association
EJ Benjamin, SS Virani, CW Callaway… - Circulation, 2018 - Am Heart Assoc
Summary Each year, the American Heart Association (AHA), in conjunction with the Centers
for Disease Control and Prevention, the National Institutes of Health, and other government …
for Disease Control and Prevention, the National Institutes of Health, and other government …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE …
Cohort profile update: the study of health in Pomerania (SHIP)
H Völzke, J Schössow, CO Schmidt… - International journal …, 2022 - academic.oup.com
The Study of Health in Pomerania (SHIP) comprises the two independent cohorts SHIP-
START (recruited between 1997 and 2001) and SHIP-TREND (recruited between 2008 to …
START (recruited between 1997 and 2001) and SHIP-TREND (recruited between 2008 to …
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
Our understanding of kidney disease pathogenesis is limited by an incomplete molecular
characterization of the cell types responsible for the organ's multiple homeostatic functions …
characterization of the cell types responsible for the organ's multiple homeostatic functions …
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
[HTML][HTML] Comparative analysis and refinement of human PSC-derived kidney organoid differentiation with single-cell transcriptomics
H Wu, K Uchimura, EL Donnelly, Y Kirita, SA Morris… - Cell stem cell, 2018 - cell.com
Kidney organoids derived from human pluripotent stem cells have great utility for
investigating organogenesis and disease mechanisms and, potentially, as a replacement …
investigating organogenesis and disease mechanisms and, potentially, as a replacement …