About twenty years ago, the functional lipid raft model of the plasma membrane was
published. It took into account decades of research showing that cellular membranes are not …

The bulk structure of biological membranes consists of a bilayer of amphipathic lipids.
According to the fluid mosaic model proposed by Singer and Nicholson, the …

Understanding how functional lipid domains in live cell membranes are generated has
posed a challenge. Here, we show that transbilayer interactions are necessary for the …

Cholesterol-mediated lipid interactions are thought to have a functional role in many
membrane-associated processes such as signalling events,,,,. Although several …

Many lipid-tethered proteins and glycolipids exist as monomers and nanoclusters on the
surface of living cells. The spatial distribution and dynamics of formation and breakup of …

Optical studies have revealed that, after binding, virions move laterally on the plasma
membrane, but the complexity of the cellular environment and the drawbacks of …

Based on recent single-molecule imaging results in the living cell plasma membrane, we
propose a hierarchical architecture of three-tiered mesoscale (2–300nm) domains to …

Several cell-surface lipid-tethered proteins exhibit a concentration-independent, cholesterol-
sensitive organization of nanoscale clusters and monomers. To understand the mechanism …

Ever since technologies enabled the characterization of eukaryotic plasma membranes,
heterogeneities in the distributions of its constituents were observed. Over the years this led …

Gangliosides, glycosphingolipids containing one or more sialic acid (s) in the glyco-chain,
are involved in various important physiological and pathological processes in the plasma …