Melt extrusion with poorly soluble drugs–An integrated review

MA Repka, S Bandari, VR Kallakunta, AQ Vo… - International journal of …, 2018 - Elsevier
Over the last few decades, hot melt extrusion (HME) has emerged as a successful
technology for a broad spectrum of applications in the pharmaceutical industry. As indicated …

Integrated continuous pharmaceutical technologies—a review

A Domokos, B Nagy, B Szilagyi, G Marosi… - … Process Research & …, 2021 - ACS Publications
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Matrix systems for oral drug delivery: Formulations and drug release

G Vasvári, J Kalmár, P Veres, M Vecsernyés… - Drug Discovery Today …, 2018 - Elsevier
In this current article matrix formulations for oral drug delivery are reviewed. Conventional
dosage forms and novel applications such as 3D printed matrices and aerogel matrices are …

Quality considerations on the pharmaceutical applications of fused deposition modeling 3D printing

A Melocchi, F Briatico-Vangosa, M Uboldi… - International Journal of …, 2021 - Elsevier
Abstract 3D printing, and particularly fused deposition modeling (FDM), has rapidly brought
the possibility of personalizing drug therapies to the forefront of pharmaceutical research …

[HTML][HTML] Development of immediate release 3D-printed dosage forms for a poorly water-soluble drug by fused deposition modeling: Study of morphology, solid state …

M Fanous, M Bitar, S Gold, A Sobczuk, S Hirsch… - International Journal of …, 2021 - Elsevier
Abstract 3D-printing technologies such as Fused Deposition Modeling (FDM) bring a unique
opportunity for personalized and flexible near-patient production of pharmaceuticals …

Tailoring immediate release FDM 3D printed tablets using a quality by design (QbD) approach

YM Than, V Titapiwatanakun - International Journal of Pharmaceutics, 2021 - Elsevier
The aims of this work were to produce immediate release printed tablets using fused
deposition modelling (FDM) technique and to systematically explore the effects of different …

Development of immediate release (IR) 3D-printed oral dosage forms with focus on industrial relevance

M Fanous, S Gold, S Hirsch, J Ogorka… - European Journal of …, 2020 - Elsevier
Pharmaceutical 3D-printing represents a potentially new dosing and manufacturing
approach for the pharmaceutical industry, with unique opportunities for personalization of …

Design and commercialization of an end-to-end continuous pharmaceutical production process: a pilot plant case study

CJ Testa, C Hu, K Shvedova, W Wu… - … Process Research & …, 2020 - ACS Publications
The pharmaceutical industry faces multiple challenges (eg, inefficient manufacturing
techniques, quality control issues, and supply chain vulnerabilities) because of its current …

Chronotherapeutic drug delivery of ketoprofen and ibuprofen for improved treatment of early morning stiffness in arthritis using hot-melt extrusion technology

NR Dumpa, S Sarabu, S Bandari, F Zhang… - AAPS PharmSciTech, 2018 - Springer
This work developed a chronotherapeutic drug delivery system (CTDDS) utilizing a potential
continuous hot-melt extrusion (HME) technique. Ketoprofen (KTP) and ibuprofen (IBU) were …

Eutectic mixture and amorphous solid dispersion: Two different supersaturating drug delivery system strategies to improve griseofulvin release using saccharin

MT França, TM Marcos, PFA Costa, GC Bazzo… - International Journal of …, 2022 - Elsevier
This study evaluated the ability of different sweeteners to improve dissolution and to form
and stabilize supersaturated solutions of griseofulvin (GSF), comparing a eutectic mixture …