Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the
receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a …

Transcriptomic analyses of postmortem brains have begun to elucidate molecular
abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in …

The proinflammatory cytokine tumor necrosis factor-α (TNFα) causes a rapid exocytosis of
AMPA receptors in hippocampal pyramidal cells and is constitutively required for the …

RNA editing by site-selective deamination of adenosine to inosine 1, 2 alters codons 3, 4
and splicing 5 in nuclear transcripts 6, and therefore protein function. ADAR2 (refs 7, 8) is a …

Gene-targeted mice lacking thel-α-amino-3-hydroxy-5-methylisoxazole-4-propionate
(AMPA) receptor subunit GluR-A exhibited normal development, life expectancy, and fine …

Unfortunately and despite all efforts, amyotrophic lateral sclerosis (ALS) remains an
incurable neurodegenerative disorder characterized by the progressive and selective death …

Excitotoxicity is one of the most extensively studied processes of neuronal cell death, and
plays an important role in many central nervous system (CNS) diseases, including CNS …

AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and
are crucial during neuronal development, synaptic plasticity and structural remodeling …

The aetiology of sporadic amyotrophic lateral sclerosis (ALS), a fatal paralytic disease, is
largely unknown. Here we show that there is a defect in the editing of the messenger RNA …