Malaria is a leading cause of morbidity and mortality in the tropics. Chemotherapeutic and
vector control strategies have been applied for more than a century but have not been …

Millions of deaths worldwide are caused by the aetiological agent of tuberculosis,
Mycobacterium tuberculosis. The increasing prevalence of this disease, the emergence of …

Genome‐scale metabolic reconstructions can serve as important tools for hypothesis
generation and high‐throughput data integration. Here, we present a metabolic network …

Dark-cutting beef is a condition in which beef fails to have a characteristic bright-red color
when the cut surface is exposed to oxygen. However, the mechanistic basis for this …

Plasmodium falciparum adenylosuccinate lyase (Pf ADSL) is an important enzyme in purine
metabolism. Although several benzimidazole derivatives have been commercially …

The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrheal
disease and an important contributor to early-childhood mortality. Waterborne outbreaks …

Recent advances in “omics” technologies have enabled the identification of new beef quality
biomarkers and have also allowed for the early detection of quality defects such as dark …

In aerobic respiration, the tricarboxylic acid cycle is pivotal to the complete oxidation of
carbohydrates, proteins, and lipids to carbon dioxide and water. Plasmodium falciparum, the …

Extensive knowledge of Chinese hamster ovary (CHO) cell metabolism is required to
improve process productivity and culture performance in biopharmaceutical manufacturing …

Members of the aspartase/fumarase superfamily share a common tertiary and quaternary
fold, as well as a similar active site architecture; the superfamily includes aspartase …