Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

The Wnt pathway is involved in several processes essential for bone development and
homeostasis. For proper functioning, the Wnt pathway is tightly regulated by numerous …

ABSTRACT DNA methylation affects expression of associated genes and may contribute to
the missing genetic effects from genome-wide association studies of osteoporosis. To …

High bone mass (HBM) can be an incidental clinical finding; however, monogenic HBM
disorders (eg, LRP5 or SOST mutations) are rare. We aimed to determine to what extent …

Osteoporosis is characterized by systemic microarchitecture impairment and bone loss,
which ultimately lead to fragility fractures. This disease is most common in older people …

Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-
miRNA sequences leading to phenotypic variability. This study aims to identify single …

Purpose Runx2 and osteocalcin have pivotal roles in bone homeostasis. Polymorphism of
these two genes could alter the function of osteoblasts and consequently bone mineral …

SOST encodes the sclerostin protein, which acts as a key extracellular inhibitor of the
canonical Wnt pathway in bone, playing a crucial role in skeletal development and bone …

The DKK1 gene encodes an extracellular inhibitor of the Wnt pathway with an important role
in bone tissue development, bone homeostasis, and different critical aspects of bone …

Background Chiari malformation type 1 (C1M) is a neurological disease characterized by
herniation of the cerebellar tonsils below the foramen magnum. Cranial bone constriction is …